director photo

Assoc. Prof. Lehtimäki

Neurosurgeon at Tampere, University hospital, Finland

Curriculum Vitae

Born 10.3.1976, Kokkola, Finland
Tampere University Hospital, Department of Neurosurgery, PO BOX 2000, 33521, Tampere

2009 Specialist in Neurosurgery
2008 PhD (Seizures and Cytokines: Experimental and Clinical Studies), University of Tampere
2003-09 Resident in neurosurgery, Tampere University Hospital
2003 Licenciate of Medicine, Medical school, University of Tampere, Finland
1995 Matricular examination, Kiviniitty High School, Kokkola, Finland

* Awards:
Max Fink ECT investigator Award, Annual meeting of the Society of Convulsive Therapy, San Fransisco, USA. 2009

* Surgical experience:

Cerebral tumors, trauma, hydrocephalus, cervical spine. Special interest to neuromodulation, DBS (epilepsy, movement disorders, psychiatric indications etc.) and VNS.

* Scientific experience:

Experimental epilepsy, biomarkers of seizure activity and neuronal injury, electroconvulsive therapy (ECT), status epilepticus, monitoring in neurointensive care, stem cells in skull defects and spinal cord injury.

* Publications:

1. Lehtimäki KA, Peltola J, Koskikallio E, Keränen T, Honkaniemi J. Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Brain Res Mol Brain Res. 2003 Feb 20;110(2):253-60.

2. Lehtimäki KA, Keränen T, Huhtala H, Hurme M, Ollikainen J, Honkaniemi J, Palmio J, Peltola J. Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration. J Neuroimmunol. 2004 Jul;152(1-2):121-5.

3. Kalueff AV, Lehtimaki KA, Ylinen A, Honkaniemi J, Peltola J. Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats. Neurosci Lett. 2004 Jul 22;365(2):106-10.

4. Lehtimäki KA, Keränen T, Palmio J, Mäkinen R, Hurme M, Honkaniemi J, Peltola J. Increased plasma levels of cytokines after seizures in localization-related epilepsy. Acta Neurol Scand. 2007 Oct;116(4):226-30.

5. Lehtimäki K, Keränen T, Huuhka M, Palmio J, Hurme M, Leinonen E, Peltola J. Increase in plasma proinflammatory cytokines after electroconvulsive therapy in patients with depressive disorder. J ECT. 2008 Mar;24(1):88-91.

6. Lehtimäki KA, Keränen T, Palmio J, Rainesalo S, Saransaari P, Peltola J. Regulation of cerebrospinal fluid levels of cytokines after seizures: the role of IL-6 and glutamic acid. Eur J Neurol. 2009; 16(4):75

7. Lehtimäki KA, Palmio J, Keänen T, Peltola J. The CSF levels of IL-1β and IL-1ra in patients with recent tonic-clonic seizures: the effect of seizure severity. Neuroimmunomodulation. 2010; 17(1):19-22.

8. Lehtimäki KA, Liimatainen S, Peltola J, Haapala A-M, Keränen T, Arvio M. Cardiolipin, β2-Glycoprotein-1 and Antinuclear Antibodies in Patients with Refractory Symptomatic Epilepsy. Seizure. 2011 Jul;20(6):438-41.

9. Lehtimäki KA, Peltola J. Keränen T, Arvio M. The serum levels of IL-6 in Patients with Intellectual Disability and Refractory Epilepsy. Epilepsy Res. Epilepsy Res. 2011 Jun;95(1-2):184-7

10. Thesleff T, Lehtimäki KA, Niskakangas T, Lindroos, Miettinen S, Suuronen R, Öhman J. Cranioplasty with adipose derived stem cells and biomaterial. Case reports of a novel method for cranial reconstruction. Neurosurgery. 2011 Jun;68(6):1535-40.

11. Sundberg M, Andersson P-H, Åkesson E, Samuelsson E-B, Holmberg L, Inzunza J, Falci S, Öhman J, Skottman H, Lehtimäki KA, Hovatta O, Narkilahti S, Sundström E. Comparison of human neural precursor cells derived from embryonic stem cells and fetal tissue: expression of differentiation and pluripotency markers and teratoma formation after cell grafting. Cell Transplant. 2010 Sep 27.

12. Liimatainen S, Lehtimäki KA, Raitala A, Peltola M, Peltola J, Hurme M. Increased indoleamine 2,3-dioxygenase (IDO) activity in idiopathic generalized epilepsy. Epilepsy Res. 2011 Mar 3.

13. Lehtimäki KA, Tähtinen T, Katisko J, Peltola J, Öhman J. The accuracy of transventricular implantation of DBS electrodes to the anterior nucleus of the thalamus for refractory epilepsy. Submitted.